Quantum Bose Josephson Junction with binary mixtures of BECs

We study the quantum behaviour of a binary mixture of Bose-Einstein condensates (BEC) in a double-well potential starting from a two-mode Bose-Hubbard Hamiltonian. We focus on the small tunneling amplitude regime and apply perturbation theory up to second order. Analytical expressions for the energy eigenvalues and eigenstates are obtained. Then the quantum evolution of the number difference of bosons between the two potential wells is fully investigated for two different initial conditions: completely localized states and coherent spin states. In the first case both the short and the long time dynamics is studied and a rich behaviour is found, ranging from small amplitude oscillations and collapses and revivals to coherent tunneling. In the second case the short-time scale evolution of number difference is determined and a more irregular dynamics is evidenced. Finally, the formation of Schroedinger cat states is considered and shown to affect the momentum distribution.Comment: 14 pages, 4 figure

Quantum dynamics of a binary mixture of BECs in a double well potential: an Holstein-Primakoff approach

We study the quantum dynamics of a binary mixture of Bose-Einstein condensates (BEC) in a double-well potential starting from a two-mode Bose-Hubbard Hamiltonian. Focussing on the regime where the number of atoms is very large, a mapping onto a SU(2) spin problem together with a Holstein-Primakoff transformation is performed. The quantum evolution of the number difference of bosons between the two wells is investigated for different initial conditions, which range from the case of a small imbalance between the two wells to a coherent spin state. The results show an instability towards a phase-separation above a critical positive value of the interspecies interaction while the system evolves towards a coherent tunneling regime for negative interspecies interactions. A comparison with a semiclassical approach is discussed together with some implications on the experimental realization of phase separation with cold atoms.Comment: 12 pages, 7 figures, accepted for publication in J. Phys.

Findings from studies are congruent with obesity having a viral origin, but what about obesity-related nafld?

Infection has recently started receiving greater attention as an unusual causative/inducing factor of obesity. Indeed, the biological plausibility of infectobesity includes direct roles of some viruses to reprogram host metabolism toward a more lipogenic and adipogenic status. Furthermore, the probability that humans may exchange microbiota components (virome/virobiota) points out that the altered response of IFN and other cytokines, which surfaces as a central mechanism for adipogenesis and obesity-associated immune suppression, is due to the fact that gut microbiota uphold intrinsic IFN signaling. Last but not least, the adaptation of both host immune and metabolic system under persistent viral infections play a central role in these phenomena. We hereby discuss the possible link between adenovirus and obesity-related nonalcoholic fatty liver disease (NAFLD). The mechanisms of adenovirus-36 (Ad-36) involvement in hepatic steatosis/NAFLD consist in reducing leptin gene expression and insulin sensitivity, augmenting glucose uptake, activating the lipogenic and pro-inflammatory pathways in adipose tissue, and increasing the level of macrophage chemoattractant protein-1, all of these ultimately leading to chronic inflammation and altered lipid metabolism. Moreover, by reducing leptin expression and secretion Ad-36 may have in turn an obesogenic effect through increased food intake or decreased energy expenditure via altered fat metabolism. Finally, Ad-36 is involved in upregulation of cAMP, phosphatidylinositol 3-kinase, and p38 signaling pathways, downregulation of Wnt10b expression, increased expression of CCAAT/enhancer binding protein-beta, and peroxisome proliferator-activated receptor gamma 2 with consequential lipid accumulation

Phase rigidity breaking in open Aharonov-Bohm ring coupled to a cantilever

The conductance and the transmittance phase shifts of a two-terminal Aharonov-Bohm (AB) ring are analyzed in the presence of mechanical displacements due to coupling to an external can- tilever. We show that phase rigidity is broken, even in the linear response regime, by means of inelastic scattering due to phonons. Our device provides a way of observing continuous variation of the transmission phase through a two-terminal nano-electro-mechanical system (NEMS). We also propose measurements of phase shifts as a way to determine the strength of the electron-phonon coupling in NEMS.Comment: 7 pages, 8 figure

Dynamical Stability of a Many-body Kapitza Pendulum

We consider a many-body generalization of the Kapitza pendulum: the periodically-driven sine-Gordon model. We show that this interacting system is dynamically stable to periodic drives with finite frequency and amplitude. This finding is in contrast to the common belief that periodically-driven unbounded interacting systems should always tend to an absorbing infinite-temperature state. The transition to an unstable absorbing state is described by a change in the sign of the kinetic term in the effective Floquet Hamiltonian and controlled by the short-wavelength degrees of freedom. We investigate the stability phase diagram through an analytic high-frequency expansion, a self-consistent variational approach, and a numeric semiclassical calculations. Classical and quantum experiments are proposed to verify the validity of our results.Comment: 11 pages, 11 figure

Atom-molecule coherence in a one-dimensional system

We study a model of one-dimensional fermionic atoms that can bind in pairs to form bosonic molecules. We show that at low energy, a coherence develops between the molecule and fermion Luttinger liquids. At the same time, a gap opens in the spin excitation spectrum. The coherence implies that the order parameters for the molecular Bose-Einstein Condensation and the atomic BCS pairing become identical. Moreover, both bosonic and fermionic charge density wave correlations decay exponentially, in contrast with a usual Luttinger liquid. We exhibit a Luther-Emery point where the systems can be described in terms of noninteracting pseudofermions. At this point, we provide closed form expressions for the density-density response functions.Comment: 5 pages, no figures, Revtex 4; (v2) added a reference to cond-mat/0505681 where related results are reported; (v3) Expression of correlation functions given in terms of generalized hypergeometric function

A mutant of phosphomannomutase1 retains full enzymatic activity, but is not activated by IMP : possible implications for the disease PMM2-CDG

The most frequent disorder of glycosylation, PMM2-CDG, is caused by a deficiency of phosphomannomutase activity. In humans two paralogous enzymes exist, both of them require mannose 1,6-bis-phosphate or glucose 1,6-bis-phosphate as activators, but only phospho-mannomutase1 hydrolyzes bis-phosphate hexoses. Mutations in the gene encoding phosphomannomutase2 are responsible for PMM2-CDG. Although not directly causative of the disease, the role of the paralogous enzyme in the disease should be clarified. Phosphomannomutase1 could have a beneficial effect, contributing to mannose 6-phosphate isomerization, or a detrimental effect, hydrolyzing the bis-phosphate hexose activator. A pivotal role in regulating mannose-1phosphate production and ultimately protein glycosylation might be played by inosine monophosphate that enhances the phosphatase activity of phosphomannomutase1. In this paper we analyzed human phosphomannomutases by conventional enzymatic assays as well as by novel techniques such as 31P-NMR and thermal shift assay. We characterized a triple mutant of phospomannomutase1 that retains mutase and phosphatase activity, but is unable to bind inosine monophosphate